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Across clinical trials (PALOMA-1, PALOMA-2, PALOMA-3), 1. Grade 3 or 4 neutropenia. Across clinical trials (PALOMA-1, onglyza product monograph PALOMA-2, PALOMA-3), 1. Grade 3 or 4 neutropenia. IBRANCE may increase plasma concentrations of IBRANCE and should be avoided.

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