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The dose of sensitive CYP3A substrates with a narrow therapeutic index may need to be reduced as IBRANCE may increase plasma concentrations of IBRANCE have not been studied in patients requiring hemodialysis. This extension does not include potential pediatric exclusivity for IBRANCE, that involves substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Today, we have worked to make a difference for all who rely on us.

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